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An. bras. dermatol ; 86(6): 1151-1158, nov.-dez. 2011. ilus, tab
Article in Portuguese | LILACS | ID: lil-610420

ABSTRACT

O conhecimento sobre a fisiopatogenia da psoríase possibilitou o desenvolvimento de ferramentas terapêuticas que visam ao bloqueio do seu gatilho imunológico. Paralelamente, citocinas como o TNF têm sido reconhecidas como integrantes da etiopatogenia da psoríase e comorbidades a ela relacionadas. Estudos genéticos e epidemiológicos contribuíram efetivamente para as conclusões a que se tem chegado atualmente sobre esta complexa patologia.


Insights into the pathogenesis of psoriasis led to the development of therapeutic tools aimed at blocking its immunological trigger. In parallel, cytokines such as the tumor necrosis factor (TNF) have been recognized as playing a crucial role in the pathogenesis of psoriasis and its associated comorbidities. Genetic and immunological studies have contributed effectively towards establishing the currently held concepts regarding this complex disease.


Subject(s)
Humans , Antigens, CD/immunology , Psoriasis/immunology , T-Lymphocytes/immunology , Tumor Necrosis Factor-alpha/immunology , Antigen-Presenting Cells/physiology , Keratinocytes/immunology , Psoriasis/pathology
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